rsRNADisease

About rsRNADisease

About the Database

rsRNADisease is a comprehensive and curated database of rRNA-derived small RNAs (rsRNAs) associated with human diseases. It integrates high-throughput small RNA sequencing datasets, systematically quantifies rsRNAs, and provides information about their origin, subtype, sequence characteristics, and disease associations.
This database is designed to facilitate the exploration of rsRNA biomarkers in disease research, offering interactive visualization, detailed annotations, and downloadable expression profiles.

Definition and Annotation of rsRNAs

rRNA-derived small RNAs (rsRNAs) are a class of small non-coding RNAs generated from ribosomal RNA (rRNA) precursors. In rsRNADisease, rsRNAs are categorized based on their rRNA origin (e.g., 5S, 5.8S, 18S, 28S) and their specific fragment location (5 end, 3 end, internal region).
All rsRNA sequences were aligned and annotated using a curated human rRNA reference, and expression quantification was performed at the transcript level to retain sequence-specific features such as length, read count, and positional information.

Citation and Contact

If you find rsRNADisease useful in your research, please cite our publication:

Huang RF, Zhang XO. rsRNADisease: a comprehensive disease-oriented database of ribosomal RNA-derived small RNAs. 2026 [DOI/link]
For questions, feedback, or data submissions, feel free to contact us at:

How to Use rsRNADisease

  • Use the rsRNA detail page to explore individual rsRNAs by origin, subtype, fragment, length, and sequence. All visualizations can be accessed by clicking on individual rsRNAs for detailed expression distribution.
  • Visit the Disease detail page to browse rsRNA biomarkers across different disease types and sample sources.
  • Navigate to the Download page to access raw and processed data files.
  • See the Manual page for detailed instructions on how to use the website.