rsRNADisease

rsRNADisease Landscape

A specialized hub for rRNA-derived small RNAs associated with human diseases

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Disease Phenotypes
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Curated Datasets
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Samples Analyzed
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rsRNA Expressions

What is rsRNA?

rRNA-derived small RNAs (rsRNAs) are a class of small non-coding RNAs generated from ribosomal RNA precursors. They are not random degradation products but functional fragments (5', 3', or internal) involved in gene regulation and disease progression.

Emerging evidence suggests that rsRNAs participate in post-transcriptional regulation, influencing mRNA stability and translation, thereby acting as crucial mediators in cellular stress responses and pathological conditions.

  • Functional fragments derived from rRNA precursors
  • Implicated in human disease progression
  • Involved in post-transcriptional gene regulation
  • Potential biomarkers for liquid biopsy
Our Mission

rsRDisease systematically quantifies rsRNAs across 1,600+ human samples to identify potential biomarkers and regulatory hotspots.

Interactive Data Explorer

Click on an organ in the body map or hover over the chart to explore tissue‑specific rsRNA expression profiles.

Body Map

Methodology & Software

rSEEK Pipeline

1. Data Collection & Preprocessing

Quality control of sRNA-seq data from public repositories.

2. rsRNA Identification

Mapping to curated rRNA references (5S, 18S, 28S, etc.) using rSEEK.

3. Quantitative Profiling

Position-specific quantification at single-nucleotide resolution.

4. Disease Association

Differential expression and Lasso regression for biomarker discovery.

rSEEK Software

Advanced toolkit for rsRNA detection and analysis. Available for standalone use.


View on GitHub Read Documentation

Related Resources

MINRBase

A resource for mitochondrial ncRNAs.

Visit Database →
rRFTargetDB

Target prediction for rRNA fragments.

Visit Database →

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